Your peripheral nervous system is in charge of sending information from your central nervous system (brain and spinal cord) to the rest of your body. The peripheral nerves also send sensory information to the nervous system.
Peripheral neuropathy is caused by damage to the nerves outside of the brain and spinal cord. This can cause weakness, numbness, and pain, usually in your hands and feet. There have been studies done from 1995-2016 exploring the connection between connective tissue disorders such as EDS and neurological manifestations including small fiber neuropathy and peripheral neuropathy.
In a study from the Iranian Journal of Neurology from October of 2014, it was found that the peripheral neuropathy in EDS patiens is related to the dislocations and subluxations that cause abnormal stretching or pressure on the peripheral nerves. They also believe that the underlying genetic defect involved with Collagen I, III, and V may cause the tissue of the peripheral nerves to fail or resist stress, causing neuropathic pain.
Signs and symptoms of peripheral neuropathy include: gradual onset of numbness, tingling in your feet or hands, extreme sensitivity to touch, sharp or burning pain, lack of coordination, muscle weakness, or pain during activities that should not cause pain, such as putting weight on them or when they are under a blanket.
If you believe you have symptoms of nerve pain or peripheral neuropathy, be sure to consult your medical professional to find out what treatment is best for you.