Endocrine Disruptors: Hidden Hazards to Hormonal Health and Their Impact on EDS, POTS, and MCAS

In today’s world, we are constantly surrounded by synthetic chemicals—from the packaging on our food to the lotion on our skin. While many of these substances are harmless, some act as silent disruptors to our hormonal systems. Known as endocrine disruptors, these chemicals can interfere with the body’s natural hormonal balance, posing serious health risks.

This is especially concerning for individuals living with Ehlers-Danlos Syndrome (EDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS), where the body’s systems are already more sensitive and reactive.

What Are Endocrine Disruptors?

Endocrine disruptors are man-made or natural compounds that can interfere with the body’s endocrine system—the intricate network of glands and hormones that regulate everything from growth and metabolism to mood and reproductive function.

These chemicals can:

• Mimic natural hormones and bind to receptors, triggering unnatural responses

• Block hormones from binding to their receptors, preventing normal function

• Disrupt the production, release, or breakdown of hormones in the body

Common Endocrine Disruptors

Some of the most common and well-studied endocrine disruptors include:

• Bisphenol A (BPA): Found in plastic containers, water bottles, and the lining of canned goods

• Phthalates: Common in cosmetics, personal care products, and soft plastics

• PBDEs (Polybrominated Diphenyl Ethers): Flame retardants found in furniture, electronics, and textiles

• PCBs (Polychlorinated Biphenyls): Industrial chemicals that persist in the environment

• DDT: A banned pesticide still found in some food chains and environments

How Endocrine Disruptors Affect the Body

The endocrine system depends on precise hormonal signaling to keep everything running smoothly. When disruptors interfere, they can cause widespread and sometimes long-lasting effects.

These disruptions can lead to:

• Reproductive Issues: Infertility, developmental abnormalities, and hormone-sensitive cancers

• Metabolic Disorders: Obesity, insulin resistance, and type 2 diabetes

• Neurological Effects: Learning disabilities, behavioral changes, and cognitive decline

• Immune Dysregulation: Greater vulnerability to infections and the potential for autoimmune conditions

Why This Matters for EDS, POTS, and MCAS

Endocrine disruptors don’t affect everyone equally. For those with EDS, POTS, and MCAS, the body’s systems are already on high alert. The added hormonal imbalance from chemical exposure can exacerbate symptoms and increase the burden on the body.

Ehlers-Danlos Syndrome (EDS)

EDS is a connective tissue disorder that affects collagen production and tissue stability. Hormonal changes—especially fluctuations in estrogen and thyroid hormones—can influence collagen synthesis and breakdown. Endocrine disruptors that mimic these hormones may further weaken connective tissues, worsening symptoms like joint instability and skin fragility.

Postural Orthostatic Tachycardia Syndrome (POTS)

POTS involves dysfunction of the autonomic nervous system, often leading to rapid heart rate, dizziness, and fatigue. Because stress hormones like norepinephrine and epinephrine help regulate blood pressure and heart rate, any chemical interference in these hormonal pathways—such as that caused by endocrine disruptors—can intensify symptoms.

Mast Cell Activation Syndrome (MCAS)

MCAS causes mast cells to release histamine and other inflammatory chemicals inappropriately. These cells are sensitive to hormonal changes, and endocrine disruptors that mimic or block hormones like estrogen and cortisol may further destabilize mast cells, worsening allergic or inflammatory reactions.

How We’re Exposed

Unfortunately, avoiding endocrine disruptors completely is nearly impossible—but awareness is the first step toward minimizing risk. Common routes of exposure include:

• Ingestion: Processed foods, pesticide residues, contaminated water

• Inhalation: Indoor air pollution from cleaning products, fragrances, and industrial emissions

• Skin contact: Personal care products, clothing treated with flame retardants, plastics

How to Reduce Your Exposure

While we can’t eliminate all exposure, these practical steps can help reduce your risk:

• Switch to BPA-free containers: Opt for glass, stainless steel, or BPA-free plastics

• Avoid microwaving plastic: Heating plastic can release harmful chemicals into food

• Check your labels: Choose phthalate- and paraben-free personal care items

• Filter your water: Use activated carbon or reverse osmosis filters to reduce contaminants

• Improve ventilation: Keep air moving indoors and reduce use of synthetic air fresheners

• Buy organic when possible: Reduce pesticide exposure by choosing organic produce when available

Final Thoughts

Endocrine disruptors may be invisible, but their impact on hormonal health is far from insignificant. For those managing complex conditions like EDS, POTS, and MCAS, understanding the role of these chemicals is critical.

By learning how they affect the body and taking small steps to reduce exposure, individuals can support their long-term well-being and give their bodies a better chance at balance and stability in an increasingly toxic world.

Awareness is empowerment—and every conscious choice adds up.